I would have replied yesterday but i have only one post per day?
So :
Yes, i play on Windows 10 64 bit in Win XP compatibility mode
Next time i'll play; i'll be sure to start ET in admin mode but maps and mods are installed automatically so ET must have granted access to install things and create config files.
Never saw the Nitmod guid, although i see that the mod is installed.
I have Punkbuster enabled.
So, that's all i have to say for today!